1. Glycosylation affects the efficacy of therapeutic proteins: for therapeutic proteins,glycosylation can also affect the half-life and targeting of protein drugs in vivo
2. Glycosylation and protein solubility: studies have shown that sugar chains on the surface of proteins can increase the molecular solubility of proteins
3. Glycosylation and protein immunogenicity:one, the sugar chain on the protein surface can induce specific immune response, on the other hand, the sugar chain can cover some epitopes on the protein surface and reduce its immunogenicity.
4. Glycosylation increases the stability of protein: glycosylation can increase the stability of protein under various denaturation conditions (such as denaturant, heat, etc.) and prevent protein aggregation. At the same time, the sugar chain on the protein surface can also cover some protease degradation sites of protein molecules, so as to increase the resistance of protein to protease
5. Glycosylation affects the biological activity of protein molecules: changing the glycosylation of protein can also make protein molecules produce new biological activity.
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